Ondansetron, a potent antiemetic agent, is a 5-hydroxytryptamine receptor 3 antagonist that blocks the effects of serotonin. It was designed originally for chemotherapy-induced nausea and vomiting. It is used to treat or prevent upset stomach and throwing up. What do I need to tell my doctor BEFORE I take Zofran? If you have an allergy to ondansetron or any other part of Zofran (ondansetron injection). A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus. Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron orally disintegrating tablet is available as a brand-name drug and a generic drug. Brand name: Zofran ODT. Ondansetron comes in four forms you take by mouth: a tablet, a disintegrating. Are over-the-counter drugs, prescription drugs, or vitamin supplements safe while you are pregnant? Find out what medications may put you or your baby at risk. Zofran (Ondansetron) is used for treating or preventing nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy. Learn which medicines are safe to take for nausea during pregnancy if home remedies don't work. This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use. Benicar® (olmesartan medoxomil) is an FDA-approved prescription hypertension drug and an angiotensin II receptor blocker (ARB). Made by Daiichi Sankyo, it lowers blood pressure by helping blood vessels relax and widen.